Chronic cystitis with bladder disorders
Physiopathology & Diagnosis
In recent years there has been an increasing number of studies advocating a significant role of glycosaminoglycans (GAGs) disorders in the pathogenesis of many chronic bladder diseases.
The loss of the GAGs layer independently of the original cause of the inflammatory process may be the first step in the cascade of events that lead to chronic bladder diseases.6
CHRONIC CYSTITIS IS MAINLY LINKED TO A DAMAGED GAG LAYER
Loss of GAGs in bladder epithelium would allow both normal and abnormal constituents of urine to come into direct contact with the subepithelial layers causing:
Normal bladder epithelium is coated by a thick layer of GAGs that acts as:6
Recurrent bacterial cystitis (RBC), interstitial cystitis (BPS / IC) and radiation can be linked in the first step of this pathogenesis.6