CYSTISTAT®, Chronic cystitis with bladder disorders

Cystitis is the medical term for bladder inflammation. The GAG layer of the bladder is deficient in cystitis. This deficiency contributes to the clinical symptoms in the “diseases” such as interstitial cystitis, cystitis caused by infections, trauma, urolithiasis, urinary retention, neoplasia and radiation induced cystitis.2

The patients can have persistent or recurrent symptoms of bladder pain: pressure or discomfort related to the bladder, usually accompanied by a frequent and urgent need to urinate at day and night.3 While the symptoms may resemble a urinary tract infection, there is no infection to be seen in the urine. Bacterial cystitis is an inflammation of the bladder usually caused by bacteria entering the bladder via the urethra. It can sometimes be referred to as a urinary tract infection (UTI).4 If repeated recurrent bacterial infections occur (i.e. three or more urinary infections per year), this is classed as recurrent bacterial cystitis (RBC).4

Cystistat® is a medical device for the temporary replacement of the deficient glycosaminoglycan (GAG) layer in the bladder, a sterile sodium hyaluronate solution containing 40 mg/50 mL sodium hyaluronate.9 It is instilled into the bladder to alleviate symptoms associated with cystitis.9

Learn more about Cystistat® and chronic cystitis with bladder disorders by visiting this website.

2. Riedl,C.R., Management of Cystitis, Business Briefing: European Pharmacotherapy 2005, 102-104.
3. Sorensen R. Chondroitin Sulphate in the Treatment of Interstitial Cystitis and Chronic Inflammatory Disease of the Urinary Bladder. European Urology Supplements 2, 2003, 16-18.
4. COB Foundation. Cystitis Handbook: The Cystitis & Overactive Bladder Foundation 2012.
5. Shao Y, Lu GL, Shen ZJ. Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation-induced hemorrhagic cystitis. BJU international. 2012;109(5):691-4.
9. Cystistat® patient information leaflet