What is Cystistat®?
Cystistat® is a medical device for the temporary replacement of the glycosaminoglycan (GAG) layer in the bladder.
The GAG layer is deficient in cystitis; Cystistat® is instilled into the bladder to alleviate symptoms associated with cystitis.
Cystistat® is supplied in a glass vial. Cystistat® is a sterile sodium hyaluronate solution containing 40 mg/50 mL sodium hyaluronate. This sterile solution is used for instillation into the bladder.
Cystistat® contains a highly purified sodium salt of hyaluronic acid (HA) produced by fermentation. HA plays a vital role in extracellular matrix homeostasis, wound healing, and tissue regeneration.15
Cystistat® has a wide range of published papers supporting the treatment of cystitis.
Cystistat® efficacy has been described in:
- Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC) 1
- Recurrent Bacterial Cystitis (RBC) by the protection of the urothelium 5, 6
- Radiation-induced cystitis (RIC) 7, 11
How does Cystistat® work?
The site of action of Cystistat® is the urothelium.
Cystistat® has been developed to temporarily replenish the deficient GAG layer on the bladder epithelium. It has a double effect:
Cystistat® has a barrier effect (primary) 8
Cystistat® also has a regenerative role (secondary effect) 15
In the urothelium, HA is predominantly found at the basal cell membrane 15
Cystistat® restores a good environment for cell proliferation 15
Cystistat® has a regenerative role of the GAG layer in the bladder 1,9